List of publications quoting the financial support of BELVIR

Notes: This list regroups manuscripts that are in press or published. Manuscripts submitted or in preparation are quoted in the scientific report. It is important to note that the BELVIR is a first generation network that was established end of 2012. In contrast to most IAP networks, BELVIR is not the continuation of a preexisting network.

Partner P1

  • Leroy, B., Gillet, L., Vanderplasschen, A. & Wattiez, R. (2016). Structural Proteomics of Herpesviruses. Viruses 8.

  • Latif, M. B., Machiels, B., Xiao, X., Mast, J., Vanderplasschen, A. & Gillet, L. (2016). Deletion of Murid Herpesvirus 4 ORF63 Affects the Trafficking of Incoming Capsids toward the Nucleus. J Virol 90, 2455-2472.

  • Boutard, B., Vankerckhove, S., Markine-Goriaynoff, N., Sarlet, M., Desmecht, D., McFadden, G., Vanderplasschen, A. & Gillet, L. (2015). The alpha2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression. PLoS One 10, e0118806.

  • Boutier, M., Ronsmans, M., Ouyang, P., Fournier, G., Reschner, A., Rakus, K., Wilkie, G. S., Farnir, F., Bayrou, C., Lieffrig, F., Li, H., Desmecht, D., Davison, A. J. & Vanderplasschen, A. (2015a). Rational development of an attenuated recombinant cyprinid herpesvirus 3 vaccine using prokaryotic mutagenesis and in vivo bioluminescent imaging. PLoS Pathog 11, e1004690.

  • Boutier, M., Ronsmans, M., Rakus, K., Jazowiecka-Rakus, J., Vancsok, C., Morvan, L., Peñaranda, M. M. D., Stone, D. M., Way, K., van Beurden, S. J., Davison, A. J. & Vanderplasschen, A. (2015b). Chapter Three - Cyprinid Herpesvirus 3: An Archetype of Fish Alloherpesviruses. In Adv Virus Res, pp. 161-256. Edited by K. M. Margaret Kielian & C. M. Thomas: Academic Press.

  • Gandar, F., Wilkie, G. S., Gatherer, D., Kerr, K., Marlier, D., Diez, M., Marschang, R. E., Mast, J., Dewals, B. G., Davison, A. J. & Vanderplasschen, A. F. (2015). The Genome of a Tortoise Herpesvirus (Testudinid Herpesvirus 3) Has a Novel Structure and Contains a Large Region That Is Not Required for Replication In Vitro or Virulence In Vivo. J Virol 89, 11438-11456.

  • Gillet, L., Frederico, B. & Stevenson, P. G. (2015). Host entry by gamma-herpesviruses--lessons from animal viruses? Curr Opin Virol 15, 34-40.

  • Kreit, M., Vertommen, D., Gillet, L. & Michiels, T. (2015). The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. PLoS One 10, e0133190.

  • Kus, K., Rakus, K., Boutier, M., Tsigkri, T., Gabriel, L., Vanderplasschen, A. & Athanasiadis, A. (2015). The Structure of the Cyprinid herpesvirus 3 ORF112-Zalpha.Z-DNA Complex Reveals a Mechanism of Nucleic Acids Recognition Conserved with E3L, a Poxvirus Inhibitor of Interferon Response. J Biol Chem 290, 30713-30725.

  • Myster, F., Palmeira, L., Sorel, O., Bouillenne, F., DePauw, E., Schwartz-Cornil, I., Vanderplasschen, A. & Dewals, B. G. (2015). Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gammaherpesvirus-induced lymphoproliferation in malignant catarrhal fever. J Virol 89, 3630-3647.

  • Ouyang, P., Rakus, K., van Beurden, S. J., Westphal, A. H., Davison, A. J., Gatherer, D. & Vanderplasschen, A. F. (2014). IL-10 encoded by viruses: a remarkable example of independent acquisition of a cellular gene by viruses and its subsequent evolution in the viral genome. J Gen Virol 95, 245-262.

  • Reddy, V. R., Steukers, L., Li, Y., Fuchs, W., Vanderplasschen, A. & Nauwynck, H. J. (2014). Replication characteristics of infectious laryngotracheitis virus in the respiratory and conjunctival mucosa. Avian Pathol 43, 450-457.

  • Ronsmans, M., Boutier, M., Rakus, K., Farnir, F., Desmecht, D., Ectors, F., Vandecan, M., Lieffrig, F., Melard, C. & Vanderplasschen, A. (2014). Sensitivity and permissivity of Cyprinus carpio to cyprinid herpesvirus 3 during the early stages of its development: importance of the epidermal mucus as an innate immune barrier. Vet Res 45, 100.

  • Machiels, B., Stevenson, P. G., Vanderplasschen, A. & Gillet, L. (2013). A gammaherpesvirus uses alternative splicing to regulate its tropism and its sensitivity to neutralization. PLoS Pathog 9, e1003753.

  • Ouyang, P., Rakus, K., Boutier, M., Reschner, A., Leroy, B., Ronsmans, M., Fournier, G., Scohy, S., Costes, B., Wattiez, R. & Vanderplasschen, A. (2013). The IL-10 homologue encoded by cyprinid herpesvirus 3 is essential neither for viral replication in vitro nor for virulence in vivo. Vet Res 44, 53.

  • Rakus, K., Ouyang, P., Boutier, M., Ronsmans, M., Reschner, A., Vancsok, C., Jazowiecka-Rakus, J. & Vanderplasschen, A. (2013). Cyprinid herpesvirus 3: an interesting virus for applied and fundamental research. Vet Res 44, 85.

  • Reschner, A., Scohy, S., Vandermeulen, G., Daukandt, M., Jacques, C., Michel, B., Nauwynck, H., Xhonneux, F., Preat, V., Vanderplasschen, A. & Szpirer, C. (2013). Use of Staby((R)) technology for development and production of DNA vaccines free of antibiotic resistance gene. Hum Vaccin Immunother 9, 2203-2210.

  • Vanderplasschen, A. A recombinant koi herpesvirus (KHV) and vaccine for the prevention of a disease caused by KHV. Application number WO2013098214A1. Publication date 04/04/2013.

  • Vidick, S., Leroy, B., Palmeira, L., Machiels, B., Mast, J., Francois, S., Wattiez, R., Vanderplasschen, A. & Gillet, L. (2013). Proteomic characterization of murid herpesvirus 4 extracellular virions. PLoS One 8, e83842.

  • Vrancken, R., Boutier, M., Ronsmans, M., Reschner, A., Leclipteux, T., Lieffrig, F., Collard, A., Melard, C., Wera, S., Neyts, J., Goris, N. & Vanderplasschen, A. (2013). Laboratory validation of a lateral flow device for the detection of CyHV-3 antigens in gill swabs. J Virol Methods 193, 679-682.

Partner P2

  • de Brogniez, A., Mast, J. & Willems, L. (2016). Determinants of the Bovine Leukemia Virus Envelope Glycoproteins Involved in Infectivity, Replication and Pathogenesis. Viruses 8.

  • Lambrecht, B., Lardinois, A., vandersleyen, o., Steensels, M., Desloges, N., Mast, j. & van den berg, T. Stronger interference of Avian Influenza than Newcastle Disease Virus specific maternal derived antibodies with a recombinant NDV-H5 vaccine. Avian Dis (in press).

  • Desimmie, B. A., Weydert, C., Schrijvers, R., Vets, S., Demeulemeester, J., Proost, P., Paron, I., De Rijck, J., Mast, J., Bannert, N., Gijsbers, R., Christ, F. & Debyser, Z. (2015). HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. Retrovirology 12, 16.

  • Gandar, F., Wilkie, G. S., Gatherer, D., Kerr, K., Marlier, D., Diez, M., Marschang, R. E., Mast, J., Dewals, B. G., Davison, A. J. & Vanderplasschen, A. F. (2015). The Genome of a Tortoise Herpesvirus (Testudinid Herpesvirus 3) Has a Novel Structure and Contains a Large Region That Is Not Required for Replication In Vitro or Virulence In Vivo. J Virol 89, 11438-11456.

  • Latif, M. B., Machiels, B., Xiao, X., Mast, J., Vanderplasschen, A. & Gillet, L. (2015). Deletion of Murid Herpesvirus 4 ORF63 Affects the Trafficking of Incoming Capsids toward the Nucleus. J Virol 90, 2455-2472.

Partner P3

  • Bannazadeh Baghi, H. & Nauwynck, H. J. (2016). Effect of equine herpesvirus type 1 (EHV-1) infection of nasal mucosa epithelial cells on integrin alpha 6 and on different components of the basement membrane. Arch Virol 161, 103-110.

  • Cho, K. J., Schepens, B., Moonens, K., Deng, L., Fiers, W., Remaut, H. & Saelens, X. (2016). Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody. J Virol 90, 611-615.

  • Li, Y., Negussie, H., Qiu, Y., Reddy, V. R. A. P., Mateusen, B. & Nauwynck, H. J. (2016). Early events of canine herpesvirus 1 infections in canine respiratory and genital mucosae by the use of ex vivo models. Res Vet Sci 105, 205-208.

  • Maelfait, J., Roose, K., Vereecke, L., Mc Guire, C., Sze, M., Schuijs, M. J., Willart, M., Ibanez, L. I., Hammad, H., Lambrecht, B. N., Beyaert, R., Saelens, X. & van Loo, G. (2016). A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection. PLoS Pathog 12, e1005410.

  • Schotsaert, M., Ysenbaert, T., Smet, A., Schepens, B., Vanderschaeghe, D., Stegalkina, S., Vogel, T. U., Callewaert, N., Fiers, W. & Saelens, X. (2016). Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies. Sci Rep 6, 24402.

  • Xiang, J., Zhang, S. & Nauwynck, H. (2016). Infections of neonatal and adult mice with murine CMV HaNa1 strain upon oronasal inoculation: New insights in the pathogenesis of natural primary CMV infections. Virus Res 211, 96-102.

  • Cho, K. J., Schepens, B., Seok, J. H., Kim, S., Roose, K., Lee, J. H., Gallardo, R., Van Hamme, E., Schymkowitz, J., Rousseau, F., Fiers, W., Saelens, X. & Kim, K. H. (2015). Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody. J Virol 89, 3700-3711.

  • Christopoulou, I., Roose, K., Ibanez, L. I. & Saelens, X. (2015). Influenza vaccines to control influenza-associated bacterial infection: where do we stand? Expert Rev Vaccines 14, 55-67.

  • De Baets, S., Verhelst, J., Van den Hoecke, S., Smet, A., Schotsaert, M., Job, E. R., Roose, K., Schepens, B., Fiers, W. & Saelens, X. (2015). A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody. PLoS One 10, e0121491.

  • Deng, L., Cho, K. J., Fiers, W. & Saelens, X. (2015a). M2e-Based Universal Influenza A Vaccines. Vaccines (Basel) 3, 105-136.

  • Deng, L., Ibanez, L. I., Van den Bossche, V., Roose, K., Youssef, S. A., de Bruin, A., Fiers, W. & Saelens, X. (2015b). Protection against Influenza A Virus Challenge with M2e-Displaying Filamentous Escherichia coli Phages. PLoS One 10, e0126650.

  • Laval, K., Favoreel, H. W., Poelaert, K. C., Van Cleemput, J. & Nauwynck, H. J. (2015). Equine Herpesvirus Type 1 Enhances Viral Replication in CD172a+ Monocytic Cells upon Adhesion to Endothelial Cells. J Virol 89, 10912-10923.

  • Li, Y., Van Cleemput, J., Qiu, Y., Reddy, V. R., Mateusen, B. & Nauwynck, H. J. (2015). Ex vivo modeling of feline herpesvirus replication in ocular and respiratory mucosae, the primary targets of infection. Virus Res 210, 227-231.

  • Reddy, V. R., Theuns, S., Roukaerts, I. D., Zeller, M., Matthijnssens, J. & Nauwynck, H. J. (2015). Genetic Characterization of the Belgian Nephropathogenic Infectious Bronchitis Virus (NIBV) Reference Strain B1648. Viruses 7, 4488-4506.

  • Zhang, S., Xiang, J., Van Doorsselaere, J. & Nauwynck, H. J. (2015). Comparison of the pathogenesis of the highly passaged MCMV Smith strain with that of the low passaged MCMV HaNa1 isolate in BALB/c mice upon oronasal inoculation. Vet Res 46, 94.

  • Baghi, H. B. & Nauwynck, H. J. (2014). Impact of equine herpesvirus type 1 (EHV-1) infection on the migration of monocytic cells through equine nasal mucosa. Comp Immunol Microbiol Infect Dis 37, 321-329.

  • Cardoso, F. M., Ibanez, L. I., Van den Hoecke, S., De Baets, S., Smet, A., Roose, K., Schepens, B., Descamps, F. J., Fiers, W., Muyldermans, S., Depicker, A. & Saelens, X. (2014). Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge. J Virol 88, 8278-8296.

  • Reddy, V. R., Steukers, L., Li, Y., Fuchs, W., Vanderplasschen, A. & Nauwynck, H. J. (2014). Replication characteristics of infectious laryngotracheitis virus in the respiratory and conjunctival mucosa. Avian Pathol 43, 450-457.

  • Schepens, B., Sedeyn, K., Vande Ginste, L., De Baets, S., Schotsaert, M., Roose, K., Houspie, L., Van Ranst, M., Gilbert, B., van Rooijen, N., Fiers, W., Piedra, P. & Saelens, X. (2014). Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein. EMBO Mol Med 6, 1436-1454.

  • Steukers, L., Weyers, S., Yang, X., Vandekerckhove, A. P., Glorieux, S., Cornelissen, M., Van den Broeck, W., Temmerman, M. & Nauwynck, H. J. (2014). Mimicking herpes simplex virus 1 and herpes simplex virus 2 mucosal behavior in a well-characterized human genital organ culture. J Infect Dis 210, 209-213.

  • Yang, X., Steukers, L., Forier, K., Xiong, R., Braeckmans, K., Van Reeth, K. & Nauwynck, H. (2014). A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus. PLoS One 9, e110026.

  • Schotsaert, M., Ysenbaert, T., Neyt, K., Ibanez, L. I., Bogaert, P., Schepens, B., Lambrecht, B. N., Fiers, W. & Saelens, X. (2013). Natural and long-lasting cellular immune responses against influenza in the M2e-immune host. Mucosal Immunol 6, 276-287.

Partner P4

  • Dao Thi, V. L., Debing, Y., Wu, X., Rice, C. M., Neyts, J., Moradpour, D. & Gouttenoire, J. (2016). Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin. Gastroenterology 150, 82-85 e84.

  • Debing, Y., Moradpour, D., Neyts, J. & Gouttenoire, J. (2016a). Update on hepatitis E virology: Implications for clinical practice. J Hepatol. (in press).

  • Debing, Y., Ramiere, C., Dallmeier, K., Piorkowski, G., Trabaud, M. A., Lebosse, F., Scholtes, C., Roche, M., Legras-Lachuer, C., de Lamballerie, X., Andre, P. & Neyts, J. (2016b). Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity. J Hepatol. (in press).

  • Drave, S. A., Debing, Y., Walter, S., Todt, D., Engelmann, M., Friesland, M., Wedemeyer, H., Neyts, J., Behrendt, P. & Steinmann, E. (2016). Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells. J Viral Hepat. (in press).

  • Helsen, N., Debing, Y., Paeshuyse, J., Dallmeier, K., Boon, R., Coll, M., Sancho-Bru, P., Claes, C., Neyts, J. & Verfaillie, C. M. (2016). Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication. J Hepatol 64, 565-573.

  • Khan, H., Paeshuyse, J., Murad, S. & Neyts, J. (2016). Assessment of the activity of directly acting antivirals and other products against different genotypes of hepatitis C virus prevalent in resource-poor countries. Antiviral Res 125, 43-45.

  • Kolawole, A. O., Rocha-Pereira, J., Elftman, M. D., Neyts, J. & Wobus, C. E. (2016). Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model. Antiviral Res 132, 46-49.

  • Musiu, S., Leyssen, P., Froeyen, M., Chezal, J. M., Neyts, J. & Paeshuyse, J. (2016). 3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase. Antiviral Res 129, 99-103.

  • Sayed, I. M., Verhoye, L., Cocquerel, L., Abravanel, F., Foquet, L., Montpellier, C., Debing, Y., Farhoudi, A., Wychowski, C., Dubuisson, J., Leroux-Roels, G., Neyts, J., Izopet, J., Michiels, T. & Meuleman, P. (2016). Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver. Gut. (in press) (10.1136/gutjnl-2015-311109).

  • Staveness, D., Abdelnabi, R., Near, K. E., Nakagawa, Y., Neyts, J., Delang, L., Leyssen, P. & Wender, P. A. (2016a). Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway. J Nat Prod 79, 680-684.

  • Staveness, D., Abdelnabi, R., Schrier, A. J., Loy, B. A., Verma, V. A., DeChristopher, B. A., Near, K. E., Neyts, J., Delang, L., Leyssen, P. & Wender, P. A. (2016b). Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death. J Nat Prod 79, 675-679.

  • Talley, D. C., Delang, L., Neyts, J., Leyssen, P. & Smith, P. J. (2016). Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors. Bioorg Med Chem Lett 26, 1196-1199.

  • Vranckx, L. S., Demeulemeester, J., Saleh, S., Boll, A., Vansant, G., Schrijvers, R., Weydert, C., Battivelli, E., Verdin, E., Cereseto, A., Christ, F., Gijsbers, R. & Debyser, Z. (2016). LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV. EBioMedicine.

  • Zmurko, J., Marques, R. E., Schols, D., Verbeken, E., Kaptein, S. J. & Neyts, J. (2016). The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model. PLoS Negl Trop Dis 10, e0004695.

  • Abdelnabi, R., Neyts, J. & Delang, L. (2015). Towards antivirals against chikungunya virus. Antiviral Res 121, 59-68.

  • Albulescu, L., Strating, J. R., Thibaut, H. J., van der Linden, L., Shair, M. D., Neyts, J. & van Kuppeveld, F. J. (2015). Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP. Antiviral Res 117, 110-114.

  • Bernard, A., Lacroix, C., Cabiddu, M. G., Neyts, J., Leyssen, P. & Pompei, R. (2015). Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds. Antivir Chem Chemother 24, 56-61.

  • De Colibus, L., Wang, X., Tijsma, A., Neyts, J., Spyrou, J. A., Ren, J., Grimes, J. M., Puerstinger, G., Leyssen, P., Fry, E. E., Rao, Z. & Stuart, D. I. (2015). Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses. PLoS Pathog 11, e1005165.

  • Debyser, Z., Christ, F., De Rijck, J. & Gijsbers, R. (2015). Host factors for retroviral integration site selection. Trends Biochem Sci 40, 108-116.

  • Delang, L., Scheers, E., Grabner, M., Verpaalen, B., Helsen, N., Vanstreels, E., Daelemans, D., Verfaillie, C. & Neyts, J. (2015). Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells. Biochem Pharmacol 96, 190-201.

  • Demeulemeester, J., De Rijck, J., Gijsbers, R. & Debyser, Z. (2015). Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection. Bioessays 37, 1202-1214.

  • Desimmie, B. A., Weydert, C., Schrijvers, R., Vets, S., Demeulemeester, J., Proost, P., Paron, I., De Rijck, J., Mast, J., Bannert, N., Gijsbers, R., Christ, F. & Debyser, Z. (2015). HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. Retrovirology 12, 16.

  • Lacroix, C., George, S., Leyssen, P., Hilgenfeld, R. & Neyts, J. (2015a). The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. Antimicrob Agents Chemother 59, 5814-5818.

  • Lacroix, C., Laconi, S., Angius, F., Coluccia, A., Silvestri, R., Pompei, R., Neyts, J. & Leyssen, P. (2015b). In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses. Virol J 12, 106.

  • Strating, J. R., van der Linden, L., Albulescu, L., Bigay, J., Arita, M., Delang, L., Leyssen, P., van der Schaar, H. M., Lanke, K. H., Thibaut, H. J., Ulferts, R., Drin, G., Schlinck, N., Wubbolts, R. W., Sever, N., Head, S. A., Liu, J. O., Beachy, P. A., De Matteis, M. A., Shair, M. D., Olkkonen, V. M., Neyts, J. & van Kuppeveld, F. J. (2015). Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep 10, 600-615.

  • Sun, L., Meijer, A., Froeyen, M., Zhang, L., Thibaut, H. J., Baggen, J., George, S., Vernachio, J., van Kuppeveld, F. J., Leyssen, P., Hilgenfeld, R., Neyts, J. & Delang, L. (2015). Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68. Antimicrob Agents Chemother 59, 7782-7785.

  • Thibaut, H. J., Lacroix, C., De Palma, A. M., Franco, D., Decramer, M. & Neyts, J. (2015). Toward antiviral therapy/prophylaxis for rhinovirus-induced exacerbations of chronic obstructive pulmonary disease: challenges, opportunities, and strategies. Rev Med Virol.

  • van der Linden, L., Vives-Adrian, L., Selisko, B., Ferrer-Orta, C., Liu, X., Lanke, K., Ulferts, R., De Palma, A. M., Tanchis, F., Goris, N., Lefebvre, D., De Clercq, K., Leyssen, P., Lacroix, C., Purstinger, G., Coutard, B., Canard, B., Boehr, D. D., Arnold, J. J., Cameron, C. E., Verdaguer, N., Neyts, J. & van Kuppeveld, F. J. (2015). The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family. PLoS Pathog 11, e1004733.

  • Zmurko, J., Neyts, J. & Dallmeier, K. (2015). Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention. Rev Med Virol 25, 205-223.

  • Borrenberghs, D., Thys, W., Rocha, S., Demeulemeester, J., Weydert, C., Dedecker, P., Hofkens, J., Debyser, Z. & Hendrix, J. (2014). HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme. ACS nano 8, 3531-3545.

  • De Houwer, S., Demeulemeester, J., Thys, W., Rocha, S., Dirix, L., Gijsbers, R., Christ, F. & Debyser, Z. (2014). The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import. J Biol Chem 289, 25351-25361.

  • El Ashkar, S., De Rijck, J., Demeulemeester, J., Vets, S., Madlala, P., Cermakova, K., Debyser, Z. & Gijsbers, R. (2014). BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements. Molecular therapy Nucleic acids 3, e179.

  • Lacroix, C., Querol-Audi, J., Roche, M., Franco, D., Froeyen, M., Guerra, P., Terme, T., Vanelle, P., Verdaguer, N., Neyts, J. & Leyssen, P. (2014). A novel benzonitrile analogue inhibits rhinovirus replication. J Antimicrob Chemother 69, 2723-2732.

  • Rocha-Pereira, J., Nascimento, M. S., Ma, Q., Hilgenfeld, R., Neyts, J. & Jochmans, D. (2014). The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon. Antimicrob Agents Chemother 58, 4675-4681.

  • Tijsma, A., Franco, D., Tucker, S., Hilgenfeld, R., Froeyen, M., Leyssen, P. & Neyts, J. (2014a). The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob Agents Chemother 58, 6990-6992.

  • Tijsma, A., Thibaut, H. J., Spieser, S. A., De Palma, A., Koukni, M., Rhoden, E., Oberste, S., Purstinger, G., Volny-Luraghi, A., Martin, J., Marchand, A., Chaltin, P., Neyts, J. & Leyssen, P. (2014b). H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1. Antiviral Res 110, 1-9.

  • Verpaalen, B., Neyts, J. & Delang, L. (2014). Are statins a viable option for the treatment of infections with the hepatitis C virus? Antiviral Res 105, 92-99.

Partner P5

  • Lardinois, C., Sorgeloos, F., Jacobs, S., van Kuppeveld, F. J., Kaspers, B. & Michiels, T. (2016). Neurotropism of Saffold virus in a mouse model. J Gen Virol. (in press) (doi: 10.1099/jgv.0.000452).

  • Sayed, I. M., Verhoye, L., Cocquerel, L., Abravanel, F., Foquet, L., Montpellier, C., Debing, Y., Farhoudi, A., Wychowski, C., Dubuisson, J., Leroux-Roels, G., Neyts, J., Izopet, J., Michiels, T. & Meuleman, P. (2016). Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver. Gut. (in press) (10.1136/gutjnl-2015-311109).

  • Drappier, M. & Michiels, T. (2015). Inhibition of the OAS/RNase L pathway by viruses. Curr Opin Virol 15, 19-26.

  • Kreit, M., Vertommen, D., Gillet, L. & Michiels, T. (2015). The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. PLoS One 10, e0133190.

  • Hermant, P., Demarez, C., Mahlakõiv, T., Staeheli, P., Meuleman, P. & Michiels, T. (2014). Human but Not Mouse Hepatocytes Respond to Interferon-Lambda In Vivo. PLoS One 9, e87906.

  • Hermant, P. & Michiels, T. (2014). Interferon-lambda in the context of viral infections: production, response and therapeutic implications. J Innate Immun 6, 563-574.

  • Hermant, P., Francius, C., Clotman, F. & Michiels, T. (2013). IFN-ε Is Constitutively Expressed by Cells of the Reproductive Tract and Is Inefficiently Secreted by Fibroblasts and Cell Lines. PLoS One 8, e71320.

Partner P6

  • De Brogniez, A., Mast, J. & Willems, L. (2016). Determinants of the Bovine Leukemia Virus Envelope Glycoproteins Involved in Infectivity, Replication and Pathogenesis. Viruses 8.

  • De Brogniez, A. & Willems, L. (2016). Viruses within animal genomes. OIE 35.

  • Gillet, N. A., Hamaidia, M., de Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K. & Willems, L. (2016). Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo. PLoS Pathog 12, e1005588.

  • Hamaidia, M., Barez, P. Y., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., Reddy, S. M., Staumont, B., Danthine, S., Deleu, M., Frederich, M., De Pauw, E., Delaplace, P., Delvigne, F., Goffin, D., Ongena, M., Duysinx, B., Louis, R., Cosse, J. P. & Willems, L. (2016a). From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound. BASE 20.

  • Hamaidia, M., Staumont, B., Duysinx, B., Louis, R. & Willems, L. (2016b). Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators. Curr Top Med Chem 16, 777-787.

  • Barez, P. Y., de Brogniez, A., Carpentier, A., Gazon, H., Gillet, N., Gutierrez, G., Hamaidia, M., Jacques, J. R., Perike, S., Neelature Sriramareddy, S., Renotte, N., Staumont, B., Reichert, M., Trono, K. & Willems, L. (2015). Recent Advances in BLV Research. Viruses 7, 6080-6088.

  • Berghmans, T., Lafitte, J.-J., Scherpereel, A., Ameye, L., Paesmans, M., Meert, A.-P., Colinet, B., Tulippe, C., Willems, L., Leclercq, N. & Sculier, J.-P. (2015). VAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study. ERJ Open Research 1, 00029-02015.

  • Carpentier, A., Barez, P. Y., Hamaidia, M., Gazon, H., de Brogniez, A., Perike, S., Gillet, N. & Willems, L. (2015). Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. Viruses 7, 3603-3624.

  • de Brogniez, A., Bouzar, A. B., Jacques, J. R., Cosse, J. P., Gillet, N., Callebaut, I., Reichert, M. & Willems, L. (2015). Mutation of a Single Envelope N-Linked Glycosylation Site Enhances the Pathogenicity of Bovine Leukemia Virus. J Virol 89, 8945-8956.

  • Hubaux, R., Vandermeers, F., Cosse, J.-P., Crisanti, C., Kapoor, V., Albelda, S. M., Mascaux, C., Delvenne, P., Hubert, P. & Willems, L. (2015). Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models. ERJ Open Research 1, 00028-02015.

  • Shiva Shankar, T. V., Sulka, B., Hubert, P., Hubaux, R., Delvenne, P., Pendeville, H., Boittiaux, I., Lambert, D. M., Wouters, J., Maillard, C., Blacher, S., Noël, A., Struman, I. & Willems, L. (2015). N-Hydroxy-6-(5-nitro-naphtalimide)-hexanamide inhibits lysine deacetylation, mitigates angiogenesis and reduces tumor growth.

    • Journal of Cancer Sciences 2, 11.
  • Willems, L. & Gillet, N. A. (2015). APOBEC3 Interference during Replication of Viral Genomes. Viruses 7, 2999-3018.

  • Berghmans, T., Ameye, L., Lafitte, J. J., Colinet, B., Cortot, A., CsToth, I., Holbrechts, S., Lecomte, J., Mascaux, C., Meert, A. P., Paesmans, M., Richez, M., Scherpereel, A., Tulippe, C., Willems, L., Dernies, T., Leclercq, N., Sculier, J. P. & European Lung Cancer Working, P. (2014). Prospective Validation Obtained in a Similar Group of Patients and with Similar High Throughput Biological Tests Failed to Confirm Signatures for Prediction of Response to Chemotherapy and Survival in Advanced NSCLC: A Prospective Study from the European Lung Cancer Working Party. Front Oncol 4, 386.

  • Gutierrez, G., Rodriguez, S. M., de Brogniez, A., Gillet, N., Golime, R., Burny, A., Jaworski, J. P., Alvarez, I., Vagnoni, L., Trono, K. & Willems, L. (2014). Vaccination against delta-retroviruses: the bovine leukemia virus paradigm. Viruses 6, 2416-2427.

  • Shiva Shankar, T. V. & Willems, L. (2014). Epigenetic modulators mitigate angiogenesis through a complex transcriptomic network. Vascul Pharmacol 60, 57-66.

  • Trono K, Willems L. 2014. A life attenuated vaccine against bovine leukemia virus. Patent PCT/EP2014/053855

  • Gillet, N. A., Gutierrez, G., Rodriguez, S. M., de Brogniez, A., Renotte, N., Alvarez, I., Trono, K. & Willems, L. (2013). Massive depletion of bovine leukemia virus proviral clones located in genomic transcriptionally active sites during primary infection. PLoS Pathog 9, e1003687.

  • Lodewick, J., Sampaio, C., Boxus, M., Rinaldi, A. S., Coulonval, K., Willems, L., Roger, P. P. & Bex, F. (2013). Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model. Retrovirology 10, 75.

  • Vandermeers, F., Neelature Sriramareddy, S., Costa, C., Hubaux, R., Cosse, J. P. & Willems, L. (2013). The role of epigenetics in malignant pleural mesothelioma. Lung Cancer 81, 311-318.

  • Gillet, N., Carpentier, A., Barez, P. Y. & Willems, L. (2012a). WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL? Retrovirology 9, 115.

  • Gillet, N., Vandermeers, F., de Brogniez, A., Florins, A., Nigro, A., Francois, C., Bouzar, A. B., Verlaeten, O., Stern, E., Lambert, D. M., Wouters, J. & Willems, L. (2012b). Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors. Pathogens 1, 65-82.

International Partner 1

  • Farrell, H. E., Lawler, C., Tan, C. S., MacDonald, K., Bruce, K., Mach, M., Davis-Poynter, N. & Stevenson, P. G. (2016). Murine Cytomegalovirus Exploits Olfaction To Enter New Hosts. MBio 7.

  • Tan, C. S., Lawler, C., May, J. S., Belz, G. T. & Stevenson, P. G. (2016). Type I Interferons Direct Gammaherpesvirus Host Colonization. PLoS Pathog 12, e1005654.

  • Chao, B., Frederico, B. & Stevenson, P. G. (2015). B-cell-independent lymphoid tissue infection by a B-cell-tropic rhadinovirus. J Gen Virol 96, 2788-2793.

  • Farrell, H. E., Davis-Poynter, N., Bruce, K., Lawler, C., Dolken, L., Mach, M. & Stevenson, P. G. (2015a). Lymph Node Macrophages Restrict Murine Cytomegalovirus Dissemination. J Virol 89, 7147-7158.

  • Farrell, H. E., Lawler, C., Oliveira, M. T., Davis-Poynter, N. & Stevenson, P. G. (2015b). Alveolar Macrophages Are a Prominent but Nonessential Target for Murine Cytomegalovirus Infecting the Lungs. J Virol 90, 2756-2766.

  • Frederico, B., Chao, B., Lawler, C., May, J. S. & Stevenson, P. G. (2015). Subcapsular sinus macrophages limit acute gammaherpesvirus dissemination. J Gen Virol 96, 2314-2327.

  • Gillet, L., Frederico, B. & Stevenson, P. G. (2015). Host entry by gamma-herpesviruses--lessons from animal viruses? Curr Opin Virol 15, 34-40.

  • Lawler, C., Milho, R., May, J. S. & Stevenson, P. G. (2015). Rhadinovirus Host Entry by Co-operative Infection. PLoS Pathog 11, 1-23.

  • Stevenson, P. (2015). Editorial overview: Viral immunology: Early events in viral infection. Curr Opin Virol 15, vii-ix.

  • Frederico, B., Chao, B., May, J. S., Belz, G. T. & Stevenson, P. G. (2014a). A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread. Cell host & microbe 15, 457-470.

  • Frederico, B., May, J. S., Efstathiou, S. & Stevenson, P. G. (2014b). BAFF receptor deficiency limits gammaherpesvirus infection. J Virol 88, 3965-3975.

  • Tan, C. S., Frederico, B. & Stevenson, P. G. (2014). Herpesvirus delivery to the murine respiratory tract. J Virol Methods 206, 105-114.

  • Tan, C. S. & Stevenson, P. G. (2014). B cell response to herpesvirus infection of the olfactory neuroepithelium. J Virol 88, 14030-14039.

  • Machiels, B., Stevenson, P. G., Vanderplasschen, A. & Gillet, L. (2013). A gammaherpesvirus uses alternative splicing to regulate its tropism and its sensitivity to neutralization. PLoS Pathog 9, e1003753.

  • Shivkumar, M., Milho, R., May, J. S., Nicoll, M. P., Efstathiou, S. & Stevenson, P. G. (2013). Herpes simplex virus 1 targets the murine olfactory neuroepithelium for host entry. J Virol 87, 10477-10488.

List of the co-publications

  • de Brogniez, A., Mast, J. & Willems, L. (2016). Determinants of the Bovine Leukemia Virus Envelope Glycoproteins Involved in Infectivity, Replication and Pathogenesis. Viruses 8. P2-P6

  • Latif, M. B., Machiels, B., Xiao, X., Mast, J., Vanderplasschen, A. & Gillet, L. (2016). Deletion of Murid Herpesvirus 4 ORF63 Affects the Trafficking of Incoming Capsids toward the Nucleus. J Virol 90, 2455-2472. P1-P2

  • Sayed, I. M., Verhoye, L., Cocquerel, L., Abravanel, F., Foquet, L., Montpellier, C., Debing, Y., Farhoudi, A., Wychowski, C., Dubuisson, J., Leroux-Roels, G., Neyts, J., Izopet, J., Michiels, T. & Meuleman, P. (2016). Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver. Gut. (in press) (10.1136/gutjnl-2015-311109). P4-P6

  • Desimmie, B. A., Weydert, C., Schrijvers, R., Vets, S., Demeulemeester, J., Proost, P., Paron, I., De Rijck, J., Mast, J., Bannert, N., Gijsbers, R., Christ, F. & Debyser, Z. (2015). HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. Retrovirology 12, 16. P2-P4

  • Gandar, F., Wilkie, G. S., Gatherer, D., Kerr, K., Marlier, D., Diez, M., Marschang, R. E., Mast, J., Dewals, B. G., Davison, A. J. & Vanderplasschen, A. F. (2015). The Genome of a Tortoise Herpesvirus (Testudinid Herpesvirus 3) Has a Novel Structure and Contains a Large Region That Is Not Required for Replication In Vitro or Virulence In Vivo. J Virol 89, 11438-11456. P1-P2

  • Gillet, L., Frederico, B. & Stevenson, P. G. (2015). Host entry by gamma-herpesviruses--lessons from animal viruses? Curr Opin Virol 15, 34-40. P1-INT1

  • Kreit, M., Vertommen, D., Gillet, L. & Michiels, T. (2015). The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. PLoS One 10, e0133190. P1-P5

  • Reddy, V. R., Steukers, L., Li, Y., Fuchs, W., Vanderplasschen, A. & Nauwynck, H. J. (2014). Replication characteristics of infectious laryngotracheitis virus in the respiratory and conjunctival mucosa. Avian Pathol 43, 450-457. P1-P3

  • Machiels, B., Stevenson, P. G., Vanderplasschen, A. & Gillet, L. (2013). A gammaherpesvirus uses alternative splicing to regulate its tropism and its sensitivity to neutralization. PLoS Pathog 9, e1003753. P1-INT1

  • Reschner, A., Scohy, S., Vandermeulen, G., Daukandt, M., Jacques, C., Michel, B., Nauwynck, H., Xhonneux, F., Preat, V., Vanderplasschen, A. & Szpirer, C. (2013). Use of Staby((R)) technology for development and production of DNA vaccines free of antibiotic resistance gene. Hum Vaccin Immunother 9, 2203-2210. P1-P3

  • Vidick, S., Leroy, B., Palmeira, L., Machiels, B., Mast, J., Francois, S., Wattiez, R., Vanderplasschen, A. & Gillet, L. (2013). Proteomic characterization of murid herpesvirus 4 extracellular virions. PLoS One 8, e83842. P1-P2

  • Vrancken, R., Boutier, M., Ronsmans, M., Reschner, A., Leclipteux, T., Lieffrig, F., Collard, A., Melard, C., Wera, S., Neyts, J., Goris, N. & Vanderplasschen, A. (2013). Laboratory validation of a lateral flow device for the detection of CyHV-3 antigens in gill swabs. J Virol Methods 193, 679-682. P1-P4

© 2013, ULg - All rights reserved - a.vdplasschen@ulg.ac.be - Prof. Alain Vanderplasschen

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